Gene Therapy: Nature Versus Man

With the advent of cutting-edge genome editing technologies such as CRISPR and the use of RNA moieties for modulation of cell function, it appears that we are at the brink of medical and scientific breakthrough in managing and potentially “fixing” disease-causing genetic mutations and defects. Just a few decades back, viral vector-mediated gene therapy and RNA interference (RNAi)-based methodologies were thought to be the panacea. Andrew Fire and Craig Mellow were awarded the Noble prize in Medicine in 2006 for describing a fundamental mechanism of gene regulation in their landmark paper published in…